靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T62705
FORMERID
TTDR01123
UNIPROID
ICOS_HUMAN
TARGNAME
Inducible T-cell costimulator (ICOS)
GENENAME
ICOS
TARGTYPE
Clinical trial target
SYNONYMS
Inducible costimulator; Inducible T-cell co-stimulator; Inducible COSTIMULATOR precursor; CD278; Activation-inducible lymphocyte immunomediatory molecule; AILIM
FUNCTION
Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
BIOCLASS
Immunoglobulin
SEQUENCE
MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL
DRUGINFO
JTX-2011
DRUGINFO
KY1044
DRUGINFO
MEDI-570
DRUGINFO
XmAb23104
KEGGPATH
hsa04514:Cell adhesion molecules (CAMs)
KEGGPATH
hsa04660:T cell receptor signaling pathway
KEGGPATH
hsa04672:Intestinal immune network for IgA production
KEGGPATH
hsa05340:Primary immunodeficiency
WIKIPATH
WP69:TCR Signaling Pathway
NET_PATH
NetPath_7:TGF_beta_Receptor Signaling Pathway
目标的 KEGG 通路数据
标题内容
hsa04514
hsa04660
hsa04672
hsa05340
目标的 Wiki 路径数据
标题内容
WP69
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Inducible T-cell costimulator (ICOS)
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