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靶点信息

标题

内容

相关药物

状态

TARGETID

T62292

FORMERID

TTDR01178

UNIPROID

GBRA3_HUMAN

TARGNAME

GABA(A) receptor alpha-3 (GABRA3)

GENENAME

GABRA3

TARGTYPE

Successful target

SYNONYMS

Gamma-aminobutyric acid receptor subunit alpha-3; GABA-A receptor alpha 3; GABA(A)Gamma-aminobutyric-acid receptor alpha-3 subunit precursor receptor; GABA(A) receptor subunit alpha-3

FUNCTION

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ

DRUGINFO

Flumazenil

DRUGINFO

Adipiplon

DRUGINFO

GSK683699

DRUGINFO

NS-2710

DRUGINFO

AZD6280

Discontinued in Phase 1

DRUGINFO

D09ACO

(2E,4S)-4-ammoniopent-2-enoate

Investigative

DRUGINFO

D0A8EU

(4R)-4-ammoniopentanoate

Investigative

DRUGINFO

D0N0ZK

(4S)-4-ammoniopentanoate

Investigative

DRUGINFO

D07JXC

[18F]fluoroethylflumazenil

Investigative

DRUGINFO

D0T9DS

[35S]TBPS

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04723	Retrograde endocannabinoid signaling
hsa04727	GABAergic synapse
hsa05032	Morphine addiction
hsa05033	Nicotine addiction

目标的 Wiki 路径数据

标题	内容
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2670	Iron uptake and transport

目标的蛋白质ID

标题	内容
TARGETID	T62292
UNIPROID	GBRA3_HUMAN
TARGNAME	GABA(A) receptor alpha-3 (GABRA3)
TARGTYPE	Successful target

目标的序列数据

标题	内容
GABA(A) receptor alpha-3 (GABRA3)	MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ

标题

内容

GABA(A) receptor alpha-3 (GABRA3)

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