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靶点信息65(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cathepsin B (CTSB)
TARGTYPE
Preclinical target
SYNONYMS
Ctsb; Cathepsins B; Cathepsin-B; Cathepsin B1; CPSB; APPS; APP secretase
FUNCTION
Cleaves matrix extracellular phosphoglycoprotein MEPE. Has also been implicated in tumor invasion and metastasis. Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
PDBSTRUC
6AY2; 5MBM; 5MBL; 3PBH; 3K9M
SEQUENCE
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
DRUGINFO
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1
DRUGINFO
PMID27998201-Compound-11
DRUGINFO
PMID27998201-Compound-12
DRUGINFO
PMID27998201-Compound-13
DRUGINFO
PMID27998201-Compound-17
DRUGINFO
PMID27998201-Compound-2
DRUGINFO
PMID27998201-Compound-22
DRUGINFO
PMID27998201-Compound-24
目标的蛋白质ID
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