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靶点信息30(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Guanylate cyclase soluble beta-1 (GUCY1B1)
TARGTYPE
Clinical trial target
SYNONYMS
Soluble guanylate cyclase small subunit; Guanylate cyclase soluble subunit beta-3; Guanylate cyclase soluble subunit beta-1; GUCY1B3; GUCSB3; GUC1B3; GCS-beta-3; GCS-beta-1
FUNCTION
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
PDBSTRUC
5MNW; 4NI2; 3UVJ; 2WZ1
BIOCLASS
Phosphorus-oxygen lyase
SEQUENCE
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
KEGGPATH
hsa00230:Purine metabolism
KEGGPATH
hsa04022:cGMP-PKG signaling pathway
KEGGPATH
hsa04270:Vascular smooth muscle contraction
KEGGPATH
hsa04540:Gap junction
KEGGPATH
hsa04611:Platelet activation
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04022 |
|
| hsa04270 |
|
| hsa04540 |
|
| hsa04611 |
|
| hsa04713 |
|
| hsa04730 |
|
| hsa04921 |
|
| hsa04970 |
|
| hsa00230 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Guanylate cyclase soluble beta-1 (GUCY1B1) |
|