TARGETID

T60930

FORMERID

TTDI02228

UNIPROID

IGF1_HUMAN

TARGNAME

Insulin-like growth factor-I (IGF1)

GENENAME

IGF1

TARGTYPE

Clinical trial target

SYNONYMS

SomatomedinC; Somatomedin-C; Mechano growth factor; Insulin-like growth factor I; IGFI; IGF-I

FUNCTION

May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1. The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

PDBSTRUC

6FF3; 5U8Q; 4XSS; 3LRI; 3GF1

SEQUENCE

MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK

DRUGINFO

Xentuzumab

DRUGINFO

BI-836845

DRUGINFO

MEDI-573

INTEPATH

avb3_integrin_pathway:Integrins in angiogenesis

INTEPATH

ceramide_pathway:Ceramide signaling pathway

INTEPATH

ecadherin_stabilization_pathway:Stabilization and expansion of the E-cadherin adherens junction

INTEPATH

er_nongenomic_pathway:Plasma membrane estrogen receptor signaling

INTEPATH

igf1_pathway:IGF1 pathway

INTEPATH

shp2_pathway:SHP2 signaling