TARGETID

T58470

FORMERID

TTDR00224

UNIPROID

CCNA2_HUMAN

TARGNAME

Cyclin A2 (CCNA2)

GENENAME

CCNA2

TARGTYPE

Literature-reported target

SYNONYMS

Cyclin-A2; Cyclin-A; Cyclin A; CCNA

FUNCTION

Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle.

PDBSTRUC

6GVA; 6ATH; 5NEV; 5LMK; 5IF1

SEQUENCE

MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL

DRUGINFO

PD-0183812

DRUGINFO

2,5-dichloro-N-p-tolylthiophene-3-sulfonamide

DRUGINFO

3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol

DRUGINFO

4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine

DRUGINFO

4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol

DRUGINFO

6-(3-Amino-benzyloxy)-9H-purin-2-ylamine

DRUGINFO

6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine

DRUGINFO

6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine

DRUGINFO

6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine

DRUGINFO

6-O-Cyclohexylmethyl Guanine