TARGETID

T58298

FORMERID

TTDR00537

UNIPROID

ENTP1_HUMAN

TARGNAME

Ectonucleoside triphosphate diphosphohydrolase 1 (CD39)

GENENAME

ENTPD1

TARGTYPE

Clinical trial target

SYNONYMS

NTPDase1; NTPDase 1; Lymphoid cell activation antigen; Ecto-nucleotidase CD-39; Ecto-apyrase; Ecto-ATPase 1; Ecto-ATPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATP diphosphohydrolase; CD39 antigen; ATPDase

FUNCTION

Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.

BIOCLASS

Acid anhydride hydrolase

ECNUMBER

EC 3.6.1.5

SEQUENCE

MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

DRUGINFO

IPH5201

DRUGINFO

SRF617

DRUGINFO

TTX-030

DRUGINFO

PSB-0963

DRUGINFO

PSB-6426

KEGGPATH

hsa00230:Purine metabolism

KEGGPATH

hsa00240:Pyrimidine metabolism

KEGGPATH

hsa05169:Epstein-Barr virus infection

BIOCPATH

PWY-7177:UTP and CTP dephosphorylation II