TARGETID

T57059

FORMERID

TTDNC00411

UNIPROID

E2F1_HUMAN

TARGNAME

E2F transcription factor 1 (E2F1)

GENENAME

E2F1

TARGTYPE

Clinical trial target

SYNONYMS

pRB-binding protein E2F-1; Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP3; RBBP-3; RBAP-1; PBR3; E2F-1

FUNCTION

The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Positively regulates transcription of RRP1B. Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.

PDBSTRUC

6G0P; 5M9O; 5M9N; 2AZE; 1O9K

SEQUENCE

MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF

DRUGINFO

ARQ-171

KEGGPATH

hsa04110:Cell cycle

KEGGPATH

hsa05161:Hepatitis B

KEGGPATH

hsa05166:HTLV-I infection

KEGGPATH

hsa05200:Pathways in cancer

KEGGPATH

hsa05206:MicroRNAs in cancer

KEGGPATH

hsa05212:Pancreatic cancer

KEGGPATH

hsa05214:Glioma

KEGGPATH

hsa05215:Prostate cancer

KEGGPATH

hsa05218:Melanoma