靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T56545

FORMERID

TTDI02020

UNIPROID

APOA1_HUMAN

TARGNAME

Apolipoprotein A-I (APOA1)

GENENAME

APOA1

TARGTYPE

Clinical trial target

SYNONYMS

Truncated apolipoprotein AI; Apolipoprotein A1; ApoAI; ApoA-I; Apo-AI

FUNCTION

As part of the SPAP complex, activates spermatozoa motility. Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).

PDBSTRUC

6CM1; 6CLZ; 6CCX; 6CCH; 6CC9

BIOCLASS

Apolipoprotein

SEQUENCE

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

DRUGINFO

CER-001

DRUGINFO

CSL-112

DRUGINFO

CER-522

DRUGINFO

MDCO-216

DRUGINFO

CRD-5

Discontinued in Phase 2

DRUGINFO

D03FPA

APP-018

Discontinued in Phase 1

DRUGINFO

AMT-050

DRUGINFO

LSI-518P

KEGGPATH

hsa03320:PPAR signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa03320	PPAR signaling pathway
hsa04975	Fat digestion and absorption
hsa04977	Vitamin digestion and absorption
hsa05143	African trypanosomiasis

目标的 Wiki 路径数据

标题	内容
WP430	Statin Pathway
WP2882	Nuclear Receptors Meta-Pathway
WP2878	PPAR Alpha Pathway
WP2806	Human Complement System
WP2797	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
WP2784	Binding and Uptake of Ligands by Scavenger Receptors
WP2776	Visual phototransduction
WP2764	Lipid digestion, mobilization, and transport
WP1780	ABC-family proteins mediated transport
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T56545
UNIPROID	APOA1_HUMAN
TARGNAME	Apolipoprotein A-I (APOA1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Apolipoprotein A-I (APOA1)	MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

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