TARGETID

T55114

FORMERID

TTDR01011

TARGNAME

Cation channel sperm-associated protein (CatSper)

TARGTYPE

Literature-reported target

SYNONYMS

Chemokine (C-C motif) receptor

FUNCTION

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.

DRUGINFO

NNC55-0396

DRUGINFO

PGF1alpha

WIKIPATH

WP2697:Fertilization