TARGETID

T51408

FORMERID

TTDC00184

UNIPROID

ADRB3_HUMAN

TARGNAME

Adrenergic receptor beta-3 (ADRB3)

GENENAME

ADRB3

TARGTYPE

Successful target

SYNONYMS

Beta3AR; Beta3-AR; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; Beta-3 adrenergic receptor; B3AR; ADRB3R

FUNCTION

Beta-3 is involved in the regulation of lipolysis and thermogenesis. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.

PDBSTRUC

2CDW

BIOCLASS

GPCR rhodopsin

SEQUENCE

MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS

DRUGINFO

Amosulalol

DRUGINFO

Bitolterol

DRUGINFO

Bopindolol

DRUGINFO

Mepindolol

DRUGINFO

Mirabegron

DRUGINFO

Nipradilol

DRUGINFO

Rimiterol

DRUGINFO

Trihexyphenidyl

DRUGINFO

Vibegron