靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T50445

FORMERID

TTDR01381

UNIPROID

TNR5_HUMAN

TARGNAME

CD40 messenger RNA (CD40 mRNA)

GENENAME

CD40

TARGTYPE

Clinical trial target

SYNONYMS

Tumor necrosis factor receptor superfamily member 5 (mRNA); TNFRSF5 (mRNA); CDw40 (mRNA); CD40L receptor (mRNA); Bp50 (mRNA); B-cell surfaceantigen CD40 (mRNA); B-cell surface antigen CD40 (mRNA)

FUNCTION

Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. Receptor for TNFSF5/CD40LG.

PDBSTRUC

6FAX; 5IHL; 5DMJ; 5DMI; 3QD6

BIOCLASS

mRNA target

SEQUENCE

MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ

DRUGINFO

NJA-730

DRUGINFO

ISIS 19211

DRUGINFO

ISIS 19212

DRUGINFO

ISIS 19213

DRUGINFO

ISIS 19217

DRUGINFO

ISIS 19218

DRUGINFO

ISIS 19219

DRUGINFO

ISIS 19220

DRUGINFO

ISIS 19221

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04064	NF-kappa B signaling pathway
hsa04514	Cell adhesion molecules (CAMs)
hsa04620	Toll-like receptor signaling pathway
hsa04672	Intestinal immune network for IgA production
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05202	Transcriptional misregulation in cancer
hsa05310	Asthma
hsa05320	Autoimmune thyroid disease
hsa05322	Systemic lupus erythematosus
hsa05330	Allograft rejection
hsa05340	Primary immunodeficiency
hsa05416	Viral myocarditis

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP453	Inflammatory Response Pathway
WP288	NLR Proteins
WP2806	Human Complement System
WP2328	Allograft Rejection
WP1449	Regulation of toll-like receptor signaling pathway

目标的蛋白质ID

标题	内容
TARGETID	T50445
UNIPROID	TNR5_HUMAN
TARGNAME	CD40 messenger RNA (CD40 mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
CD40 messenger RNA (CD40 mRNA)	MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ

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