靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T48598

FORMERID

TTDNC00549

UNIPROID

RASK_HUMAN

TARGNAME

GTPase KRas (KRAS)

GENENAME

KRAS

TARGTYPE

Clinical trial target

SYNONYMS

c-Ki-ras; c-K-ras; RASK2; Ki-Ras; KRAS2; K-Ras 2

FUNCTION

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

PDBSTRUC

6N2K; 6N2J; 6H47; 6H46; 6GQY

BIOCLASS

Small GTPase

SEQUENCE

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM

DRUGINFO

AZD4785

DRUGINFO

BI 1701963

KEGGPATH

hsa01521:EGFR tyrosine kinase inhibitor resistance

KEGGPATH

hsa01522:Endocrine resistance

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04062:Chemokine signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04062	Chemokine signaling pathway
hsa04068	FoxO signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04072	Phospholipase D signaling pathway
hsa04137	Mitophagy - animal
hsa04140	Autophagy - animal
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04210	Apoptosis
hsa04211	Longevity regulating pathway
hsa04213	Longevity regulating pathway - multiple species
hsa04218	Cellular senescence
hsa04360	Axon guidance
hsa04370	VEGF signaling pathway
hsa04371	Apelin signaling pathway
hsa04540	Gap junction
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04625	C-type lectin receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04714	Thermogenesis
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04725	Cholinergic synapse
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04915	Estrogen signaling pathway
hsa04916	Melanogenesis
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04926	Relaxin signaling pathway
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa04960	Aldosterone-regulated sodium reabsorption
hsa05034	Alcoholism
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05163	Human cytomegalovirus infection
hsa05165	Human papillomavirus infection
hsa05166	Human T-cell leukemia virus 1 infection
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer
hsa05224	Breast cancer
hsa05225	Hepatocellular carcinoma
hsa05226	Gastric cancer
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa01522	Endocrine resistance
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T48598
UNIPROID	RASK_HUMAN
TARGNAME	GTPase KRas (KRAS)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
GTPase KRas (KRAS)	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM

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