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靶点信息21(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interleukin 15 receptor alpha (IL15RA)
TARGTYPE
Clinical trial target
SYNONYMS
sIL15Ralpha; sIL15RA; sIL15 receptor subunit alpha; Soluble interleukin15 receptor subunit alpha; Interleukin-15 receptor subunit alpha; IL15Ralpha; IL15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; CD215
FUNCTION
Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. High-affinity receptor for interleukin-15.
PDBSTRUC
4GS7; 2Z3R; 2Z3Q; 2ERS
BIOCLASS
Cytokine receptor
SEQUENCE
MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04630:Jak-STAT signaling pathway
KEGGPATH
hsa04672:Intestinal immune network for IgA production
KEGGPATH
hsa05166:HTLV-I infection
WIKIPATH
WP69:TCR Signaling Pathway
NET_PATH
NetPath_11:TCR Signaling Pathway
NET_PATH
NetPath_13:IL1 Signaling Pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04630 |
|
| hsa04672 |
|
| hsa05166 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Interleukin 15 receptor alpha (IL15RA) |
|