TARGETID

T47863

FORMERID

TTDR00765

UNIPROID

EPCAM_HUMAN

TARGNAME

Tumor-associated calcium signal transducer 1 (EPCAM)

GENENAME

EPCAM

TARGTYPE

Clinical trial target

SYNONYMS

hEGP314; TROP1; TACSTD1; Major gastrointestinal tumor-associated protein GA733-2; MIC18; M4S1; M1S2; KSA; KS 1/4 antigen; Gastrointestinal carcinoma antigen GA733; GA733-2; Epithelial glycoprotein 314; Epithelial glycoprotein; Epithelial cell surface antigen; Epithelial cell adhesion molecule; Ep-CAM; EGP314; EGP; Cell surface glycoprotein Trop-1; CD326; Adenocarcinoma-associated antigen

FUNCTION

Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection.

PDBSTRUC

6I07; 4MZV

SEQUENCE

MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA

DRUGINFO

Vicineum

DRUGINFO

VB4-845

DRUGINFO

CAR-T Cells targeting EpCAM

DRUGINFO

A-337

DRUGINFO

CAR-T cells recognizing EpCAM

DRUGINFO

CAR-T cells targeting EpCAM

DRUGINFO

Citatuzumab bogatox

DRUGINFO

ING-1

DRUGINFO

MT-110

DRUGINFO

EPCAM-targeted CAR-T cells