TARGETID

T47610

FORMERID

TTDS00501

UNIPROID

I11RA_HUMAN

TARGNAME

Interleukin 11 receptor alpha (IL11RA)

GENENAME

IL11RA

TARGTYPE

Successful target

SYNONYMS

Interleukin-11 receptor subunit alpha; IL-11RA; IL-11R-alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha

FUNCTION

The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Receptor for interleukin-11.

BIOCLASS

Cytokine receptor

SEQUENCE

MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL

DRUGINFO

Oprelvekin

DRUGINFO

UNI-rhIL-11

DRUGINFO

BMTP-11

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04630:Jak-STAT signaling pathway

KEGGPATH

hsa04640:Hematopoietic cell lineage

WIKIPATH

WP2332:Interleukin-11 Signaling Pathway

PANTPATH

P00036:Interleukin signaling pathway