TARGETID

T46360

FORMERID

TTDS00129

UNIPROID

SGMR1_HUMAN

TARGNAME

Opioid receptor sigma 1 (OPRS1)

GENENAME

SIGMAR1

TARGTYPE

Successful target

SYNONYMS

hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8

FUNCTION

Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112. Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane.

PDBSTRUC

6DK1; 6DK0; 6DJZ; 5HK2; 5HK1

BIOCLASS

GPCR rhodopsin

SEQUENCE

MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP

DRUGINFO

Dextromethorphan

DRUGINFO

Dextromethorphan Polistirex

DRUGINFO

ADX N05

DRUGINFO

AVP-786

DRUGINFO

CM-2395

DRUGINFO

Igmesine

DRUGINFO

OPC-14523

DRUGINFO

ANAVEX 2-73

DRUGINFO

SA-5845