TARGETID

T46185

FORMERID

TTDS00003

UNIPROID

ACM2_HUMAN

TARGNAME

Muscarinic acetylcholine receptor M2 (CHRM2)

GENENAME

CHRM2

TARGTYPE

Successful target

SYNONYMS

M2 receptor; CHRM2

FUNCTION

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

PDBSTRUC

6OIK; 5ZKC; 5ZKB; 5ZK8; 5ZK3

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

DRUGINFO

ACECLIDINE

DRUGINFO

Gallamine Triethiodide

DRUGINFO

Methacholine Chloride

DRUGINFO

Methylscopolamine

DRUGINFO

SMT-D002

DRUGINFO

FP-1097

DRUGINFO

Otenzepad

DRUGINFO

PSD-506

DRUGINFO

SCH-211803