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靶点信息66(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Sigma intracellular receptor 2 (TMEM97)
TARGTYPE
Clinical trial target
SYNONYMS
Transmembrane protein 97; Sigma2 receptor; Sigma-2 receptor; Meningioma-associated protein 30; MAC30
FUNCTION
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
BIOCLASS
TMEM97/sigma-2 receptor
SEQUENCE
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
DRUGINFO
Aryl azepine derivative 1
DRUGINFO
Aryl azepine derivative 2
DRUGINFO
Benzamide derivative 1
DRUGINFO
Benzamide derivative 10
DRUGINFO
Benzamide derivative 11
DRUGINFO
Benzamide derivative 2
DRUGINFO
Benzamide derivative 3
DRUGINFO
Benzamide derivative 4
DRUGINFO
Benzamide derivative 7
目标的蛋白质ID
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Sigma intracellular receptor 2 (TMEM97) |
|