TARGETID

T45591

FORMERID

TTDI02137

UNIPROID

NPM_HUMAN

TARGNAME

Nucleophosmin (NPM1)

GENENAME

NPM1

TARGTYPE

Clinical trial target

SYNONYMS

Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM

FUNCTION

Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.

PDBSTRUC

5EHD; 2VXD; 2P1B; 2LLH

SEQUENCE

MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL

DRUGINFO

IPP-204106

WIKIPATH

WP1874:Nucleosome assembly

WIKIPATH

WP2684:Host Interactions of HIV factors

INTEPATH

aurora_b_pathway:Aurora B signaling

INTEPATH

bard1pathway:BARD1 signaling events

INTEPATH

hif1_tfpathway:HIF-1-alpha transcription factor network

INTEPATH

myc_activpathway:Validated targets of C-MYC transcriptional activation