TARGETID

T45299

FORMERID

TTDR01233

UNIPROID

TPA_HUMAN

TARGNAME

Tissue-type plasminogen activator (PLAT)

GENENAME

PLAT

TARGTYPE

Successful target

SYNONYMS

TPA; T-plasminogen activator; T-PA; Reteplase; Alteplase

FUNCTION

By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen.

PDBSTRUC

5ZLZ; 5BRR; 1TPN; 1TPM; 1TPK

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.68

SEQUENCE

MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP

DRUGINFO

Aminocaproic Acid

DRUGINFO

1-guanidino-N-phenyl-7-isoquinolinesulphonamide

DRUGINFO

2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine

DRUGINFO

5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID

DRUGINFO

BMS-344577

DRUGINFO

N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine

DRUGINFO

N-(4-Phenyl-pyridin-2-yl)-guanidine

DRUGINFO

N-(5-Benzyloxy-isoquinolin-1-yl)-guanidine