TARGETID

T45262

FORMERID

TTDC00073

UNIPROID

CRFR1_HUMAN

TARGNAME

Corticotropin-releasing factor receptor 1 (CRHR1)

GENENAME

CRHR1

TARGTYPE

Successful target

SYNONYMS

Corticotropin-releasing hormone type 1 receptor; Corticotropin-releasing hormone receptor 1; CRHR1; CRH-R 1; CRF1; CRF-R1; CRF-R; CRF-1 receptor; CRF receptor

FUNCTION

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

PDBSTRUC

4Z9G; 4K5Y; 3EHU; 3EHT; 3EHS

BIOCLASS

GPCR secretin

SEQUENCE

MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV

DRUGINFO

Telavancin

DRUGINFO

Pexacerfont

DRUGINFO

GSK561679

DRUGINFO

ONO-2333Ms

DRUGINFO

SSR125543

DRUGINFO

GSK586529

DRUGINFO

CP-316,311

DRUGINFO

GW876008

DRUGINFO

CRA1000