靶点信息31(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Tryptophan 2,3-dioxygenase (TDO)
TARGTYPE
Clinical trial target
SYNONYMS
Tryptophanase; Tryptophan pyrrolase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO; TO
FUNCTION
Catalyzes the oxidative cleavage of the indole moiety. Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.
PDBSTRUC
6A4I; 5TIA; 5TI9; 4PW8
SEQUENCE
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 1
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 2
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 3
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 4
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 5
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 6
DRUGINFO
2,3-diamino-benzo[b]thiophene derivative 7
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| "Tryptophan 2,3-dioxygenase (TDO)" |
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