靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T44771

FORMERID

TTDI02306

UNIPROID

TGFB2_HUMAN

TARGNAME

TGF beta-2 messenger RNA (TGFB2 mRNA)

GENENAME

TGFB2

TARGTYPE

Clinical trial target

SYNONYMS

Transforming growth factor beta-2 proprotein (mRNA); TGF-beta 2 (mRNA); Polyergin (mRNA); Glioblastoma-derived T-cell suppressor factor (mRNA); G-TSF (mRNA); Cetermin (mRNA); BSC-1 cell growth inhibitor (mRNA)

FUNCTION

Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.

PDBSTRUC

5TY4; 5TX4; 4KXZ; 2TGI; 1TFG

BIOCLASS

mRNA target

SEQUENCE

MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

DRUGINFO

Belagenpumatucel-L

DRUGINFO

OT-101

DRUGINFO

Ranagengliotucel-T

Discontinued in Phase 3

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04110:Cell cycle

KEGGPATH

hsa04144:Endocytosis

KEGGPATH

hsa04350:TGF-beta signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04068	FoxO signaling pathway
hsa04110	Cell cycle
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa04390	Hippo signaling pathway
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05161	Hepatitis B
hsa05166	HTLV-I infection
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05321	Inflammatory bowel disease (IBD)
hsa05323	Rheumatoid arthritis
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy

目标的 Wiki 路径数据

标题	内容
WP474	Endochondral Ossification
WP400	p38 MAPK Signaling Pathway
WP382	MAPK Signaling Pathway
WP2884	NRF2 pathway
WP2870	Extracellular vesicle-mediated signaling in recipient cells
WP2703	Extracellular matrix organization
WP2666	Elastic fibre formation

目标的蛋白质ID

标题	内容
TARGETID	T44771
UNIPROID	TGFB2_HUMAN
TARGNAME	TGF beta-2 messenger RNA (TGFB2 mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
TGF beta-2 messenger RNA (TGFB2 mRNA)	MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

标题

内容

TGF beta-2 messenger RNA (TGFB2 mRNA)

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