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靶点信息35(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Gap junction alpha-1 protein (GJA1)
TARGTYPE
Clinical trial target
SYNONYMS
Gap junction 43 kDa heart protein; GJAL; Cx43; Connexin-43; Connexin 43
FUNCTION
A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles. Gap junction protein that acts as a regulator of bladder capacity.
BIOCLASS
Gap junction-forming connexin
SEQUENCE
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
KEGGPATH
hsa04540:Gap junction
KEGGPATH
hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)
WIKIPATH
WP1820:Gap junction trafficking and regulation
WIKIPATH
WP1992:TarBasePathway
WIKIPATH
WP2002:miR-targeted genes in epithelium - TarBase
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP706 |
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| WP536 |
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| WP437 |
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| WP363 |
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| WP289 |
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| WP2431 |
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| WP2355 |
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| WP2118 |
|
| WP2005 |
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| WP2002 |
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| WP1992 |
|
| WP1820 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Gap junction alpha-1 protein (GJA1) |
|