TARGETID

T43721

FORMERID

TTDR01269

UNIPROID

DHI2_HUMAN

TARGNAME

Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)

GENENAME

HSD11B2

TARGTYPE

Clinical trial target

SYNONYMS

NAD-dependent 11-beta-hydroxysteroid dehydrogenase; HSD11B2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; 11-DH2; 11 beta-hydroxysteroid dehydrogenase type 2; 11 beta-HSD2

FUNCTION

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

BIOCLASS

Short-chain dehydrogenases reductase

ECNUMBER

EC 1.1.1.-

SEQUENCE

MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR

DRUGINFO

RG-7234

DRUGINFO

[(125)I] RB129

DRUGINFO

11-keto-beta-boswellicacid

DRUGINFO

3-acetyl-11-keto-beta-boswellic acid

DRUGINFO

Ganoderic acid A

KEGGPATH

hsa00140:Steroid hormone biosynthesis

KEGGPATH

hsa04960:Aldosterone-regulated sodium reabsorption

WIKIPATH

WP237:Glucocorticoid & Mineralcorticoid Metabolism

WIKIPATH

WP98:Prostaglandin Synthesis and Regulation