TARGETID

T43332

FORMERID

TTDR00947

UNIPROID

FA7_HUMAN

TARGNAME

Coagulation factor VII (F7)

GENENAME

F7

TARGTYPE

Successful target

SYNONYMS

Serum prothrombin conversion accelerator; SPCA; Proconvertin; Eptacog alfa

FUNCTION

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

PDBSTRUC

5U6J; 5TQG; 5TQF; 5TQE; 5PB6

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.21

SEQUENCE

MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP

DRUGINFO

Factor viia

DRUGINFO

BAX-817

DRUGINFO

Vatreptacog alfa (activated)

DRUGINFO

Activated recombinant FVII-albumin fusion protein

DRUGINFO

Recombinant factor VIIa PEGylated liposomal

DRUGINFO

CB-813

DRUGINFO

Eptacog alfa

DRUGINFO

F-7TG