靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T42928

FORMERID

TTDI02071

UNIPROID

FGF21_HUMAN

TARGNAME

Fibroblast growth factor-21 (FGF21)

GENENAME

FGF21

TARGTYPE

Clinical trial target

SYNONYMS

UNQ3115/PRO10196; Fibroblast growth factor 21; FGF-21

FUNCTION

Activity requires the presence of KLB. Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression).

PDBSTRUC

5VAQ

BIOCLASS

Growth factor

SEQUENCE

MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS

DRUGINFO

BMS-986036

DRUGINFO

PF-05231023

DRUGINFO

FGF-21

Discontinued in Phase 1/2

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04810:Regulation of actin cytoskeleton

KEGGPATH

hsa05200:Pathways in cancer

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05218	Melanoma

目标的 Wiki 路径数据

标题	内容
WP51	Regulation of Actin Cytoskeleton
WP2586	Aryl Hydrocarbon Receptor
WP1982	SREBP signalling

目标的蛋白质ID

标题	内容
TARGETID	T42928
UNIPROID	FGF21_HUMAN
TARGNAME	Fibroblast growth factor-21 (FGF21)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Fibroblast growth factor-21 (FGF21)	MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS

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