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靶点信息14(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Melanoma-associated antigen 1 (MAGEA1)
TARGTYPE
Clinical trial target
SYNONYMS
Melanomaassociated antigen 1; MAGE1A; MAGE1 antigen; MAGE1; MAGE-1 antigen; Cancer/testis antigen 1.1; CT1.1; Antigen MZ2E; Antigen MZ2-E
FUNCTION
May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1.
BIOCLASS
Melanoma associated antigen
SEQUENCE
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV
DRUGINFO
CAR-T cells targeting MAGE-A1
DRUGINFO
Melanoma vaccine (ALVAC)
WIKIPATH
WP61:Notch Signaling Pathway
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Melanoma-associated antigen 1 (MAGEA1) |
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