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靶点信息

标题

内容

相关药物

状态

TARGETID

T42822

FORMERID

TTDS00437

UNIPROID

HEMH_HUMAN

TARGNAME

Ferrochelatase (FECH)

GENENAME

FECH

TARGTYPE

Successful target

SYNONYMS

Protoheme ferro-lyase; Heme synthetase; FECH

FUNCTION

Catalyzes the ferrous insertion into protoporphyrin IX.

PDBSTRUC

4MK4; 4KMM; 4KLR; 4KLC; 4KLA

BIOCLASS

Ferrochelatase

ECNUMBER

EC 4.99.1.1

SEQUENCE

MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL

DRUGINFO

D0OR2L

Cholic Acid

Approved

DRUGINFO

D0OL6O

Methyl aminolevulinate

DRUGINFO

Lead acetate

DRUGINFO

N-Methylmesoporphyrin

Investigative

DRUGINFO

D00GJZ

N-Methylmesoporphyrin Containing Copper

Investigative

KEGGPATH

hsa00860:Porphyrin and chlorophyll metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP1852:Metabolism of porphyrins

目标的 KEGG 通路数据

标题	内容
hsa00860	Porphyrin and chlorophyll metabolism
hsa01100	Metabolic pathways

目标的 Wiki 路径数据

标题	内容
WP561	Heme Biosynthesis
WP1852	Metabolism of porphyrins

目标的蛋白质ID

标题	内容
TARGETID	T42822
UNIPROID	HEMH_HUMAN
TARGNAME	Ferrochelatase (FECH)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Ferrochelatase (FECH)	MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL

标题

内容

Ferrochelatase (FECH)

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