TARGETID

T42724

FORMERID

TTDI03310

UNIPROID

KCNN4_HUMAN

TARGNAME

Calcium-activated potassium channel KCa3.1 (KCNN4)

GENENAME

KCNN4

TARGTYPE

Clinical trial target

SYNONYMS

SKCa4; SKCa 4; SK4; Putative Gardos channel; KCa4; KCa3.1; Intermediate conductance calcium-activated potassium channel protein 4; IKCa1; IK1

FUNCTION

Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis. Forms a voltage-independent potassium channel that is activated by intracellular calcium.

PDBSTRUC

6D42; 6CNO; 6CNN; 6CNM

BIOCLASS

Voltage-gated ion channel

SEQUENCE

MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK

DRUGINFO

ASP0819

DRUGINFO

ICA-17043

DRUGINFO

1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole

DRUGINFO

DC-EBIO

DRUGINFO

EBIO

DRUGINFO

PMID15603962Crac-16

DRUGINFO

SKA-121

DRUGINFO

SKA-31