靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T28893

FORMERID

TTDS00002

UNIPROID

ACM1_HUMAN

TARGNAME

Muscarinic acetylcholine receptor M1 (CHRM1)

GENENAME

CHRM1

TARGTYPE

Successful target

SYNONYMS

M1 receptor

FUNCTION

Primary transducing effect is Pi turnover. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

PDBSTRUC

6OIJ; 5CXV

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

DRUGINFO

ACECLIDINE

DRUGINFO

Benztropine

DRUGINFO

Biperiden

DRUGINFO

Clidinium

DRUGINFO

Cycrimine

DRUGINFO

Dicyclomine

DRUGINFO

Diphemanil Methylsulfate

Approved

DRUGINFO

D00BLL

Fesoterodine fumarate

Approved

DRUGINFO

D0M0AM

Glycopyrrolate

Approved

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04725	Cholinergic synapse
hsa04810	Regulation of actin cytoskeleton

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP536	Calcium Regulation in the Cardiac Cell
WP51	Regulation of Actin Cytoskeleton
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP2597	Secretion of Hydrochloric Acid in Parietal Cells
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T28893
UNIPROID	ACM1_HUMAN
TARGNAME	Muscarinic acetylcholine receptor M1 (CHRM1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Muscarinic acetylcholine receptor M1 (CHRM1)	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

标题

内容

Muscarinic acetylcholine receptor M1 (CHRM1)

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