TARGETID

T28887

FORMERID

TTDR01337

UNIPROID

HDAC8_HUMAN

TARGNAME

Histone deacetylase 8 (HDAC8)

GENENAME

HDAC8

TARGTYPE

Clinical trial target

SYNONYMS

Histone deacetylase-8; HDACL1; HD8; CDA07

FUNCTION

Gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

PDBSTRUC

6HSK; 5VI6; 5THV; 5THU; 5THT

BIOCLASS

Carbon-nitrogen hydrolase

ECNUMBER

EC 3.5.1.98

SEQUENCE

MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV

DRUGINFO

NBM-BMX

DRUGINFO

PMID29671355-Compound-13

DRUGINFO

PMID29671355-Compound-21

DRUGINFO

PMID29671355-Compound-23

DRUGINFO

PMID29671355-Compound-25

DRUGINFO

PMID29671355-Compound-31

DRUGINFO

PMID29671355-Compound-36

DRUGINFO

PMID29671355-Compound-37