TARGETID

T28869

FORMERID

TTDS00479

UNIPROID

URE1_KLEAE

TARGNAME

Bacterial Urease (Bact ureC)

GENENAME

Bact ureC

TARGTYPE

Successful target

SYNONYMS

Urease subunit alpha; Urea amidohydrolase subunit alpha

FUNCTION

Catalyzes the hydrolysis of urea, leading to the production of carbon dioxide and ammonia. Allows many soil bacteria to use urea as a nitrogen source. An important virulence factor that improves survival of pathogenic bacteria under acidic conditions within the host and can also cause direct damage to the host tissue due to ammonia, CO2 or alkali production.

PDBSTRUC

4EPE; 4EPD; 4EPB; 4EP8; 2KAU

BIOCLASS

Carbon-nitrogen hydrolase

SEQUENCE

MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLAADCVDLVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVTAGGIDTHIHWICPQQAEEALVSGVTTMVGGGTGPAAGTHATTCTPGPWYISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIHEDWGATPAAIDCALTVADEMDIQVALHSDTLNESGFVEDTLAAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTLNTIDEHLDMLMVCHHLDPDIAEDVAFAESRIRRETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVILRTWQVAHRMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSPAFFGVKPATVIKGGMIAIAPMGDINASIPTPQPVHYRPMFGALGSARHHCRLTFLSQAAAANGVAERLNLRSAIAVVKGCRTVQKADMVHNSLQPNITVDAQTYEVRVDGELITSEPADVLPMAQRYFLF

DRUGINFO

Acetohydroxamic Acid

DRUGINFO

1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea

DRUGINFO

3-(4-bromobenzyl)-1,1-dimethylselenourea

DRUGINFO

3-(4-bromophenyl)-1,1-dimethylthiourea

DRUGINFO

3-dodecyl-1,1-dimethylthiourea

DRUGINFO

N-glycylglycinehydroxamic acid