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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
GTP cyclohydrolase-I (GCH1)
TARGTYPE
Clinical trial target
SYNONYMS
Guanosine triphosphate cyclohydrolase I; GTP-CH-I; GTP cyclohydrolase I; GTP cyclohydrolase 1; GCH; DYT5
FUNCTION
May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs).
BIOCLASS
Carbon-nitrogen hydrolase
SEQUENCE
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
DRUGINFO
2-Propanol, Isopropanol
DRUGINFO
8-hydroxyguanine
DRUGINFO
Guanosine-5'-Triphosphate
WHIZPATH
PW000140:Pterine Biosynthesis
REACPATH
R-HSA-1474151:Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
目标的蛋白质ID
| 标题 | 内容 |
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| GTP cyclohydrolase-I (GCH1) |
|