TARGETID

T26226

FORMERID

TTDC00333

UNIPROID

PRLR_HUMAN

TARGNAME

Prolactin receptor (PRLR)

GENENAME

PRLR

TARGTYPE

Clinical trial target

SYNONYMS

PRL-R

FUNCTION

Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This is a receptor for the anterior pituitary hormone prolactin (PRL).

PDBSTRUC

4I18; 3NCF; 3NCE; 3NCC; 3NCB

BIOCLASS

Cytokine receptor

SEQUENCE

MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH

DRUGINFO

Endostatin

DRUGINFO

LFA-102

DRUGINFO

Prolanta

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04630:Jak-STAT signaling pathway

KEGGPATH

hsa04917:Prolactin signaling pathway

WIKIPATH

WP236:Adipogenesis