靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T26203

FORMERID

TTDI01933

UNIPROID

ICAM1_HUMAN

TARGNAME

Intercellular adhesion molecule ICAM-1 (ICAM1)

GENENAME

ICAM1

TARGTYPE

Successful target

SYNONYMS

Major group rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; CD54

FUNCTION

During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

PDBSTRUC

6EIT; 5MZA; 3TCX; 2OZ4; 1Z7Z

BIOCLASS

Immunoglobulin

SEQUENCE

MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

DRUGINFO

lifitegrast

DRUGINFO

Alicaforsen

DRUGINFO

APC-8015F

DRUGINFO

BI-505

DRUGINFO

AIC100

DRUGINFO

A-252444.0

DRUGINFO

GI-270384X

DRUGINFO

MOR-102

DRUGINFO

ISIS-1939

目标的 KEGG 通路数据

标题	内容
hsa04064	NF-kappa B signaling pathway
hsa04514	Cell adhesion molecules (CAMs)
hsa04650	Natural killer cell mediated cytotoxicity
hsa04668	TNF signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa05143	African trypanosomiasis
hsa05144	Malaria
hsa05150	Staphylococcus aureus infection
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05323	Rheumatoid arthritis
hsa05416	Viral myocarditis

目标的 Wiki 路径数据

标题	内容
WP619	Type II interferon signaling (IFNG)
WP2865	IL1 and megakaryotyces in obesity
WP2806	Human Complement System
WP2431	Spinal Cord Injury
WP2332	Interleukin-11 Signaling Pathway
WP2018	RANKL/RANK Signaling Pathway
WP1833	Integrin cell surface interactions
WP1829	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T26203
UNIPROID	ICAM1_HUMAN
TARGNAME	Intercellular adhesion molecule ICAM-1 (ICAM1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Intercellular adhesion molecule ICAM-1 (ICAM1)	MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

标题

内容

Intercellular adhesion molecule ICAM-1 (ICAM1)

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