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靶点信息43(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Free fatty acid receptor 1 (GPR40)
TARGTYPE
Clinical trial target
SYNONYMS
Gprotein coupled receptor 40; FFAR1
FUNCTION
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
PDBSTRUC
5TZY; 5TZR; 5KW2; 4PHU
SEQUENCE
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
DRUGINFO
Fasiglifam hemihydrate
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP455 |
|
| WP2728 |
|
| WP2664 |
|
| WP1831 |
|
| WP1825 |
|
| WP1824 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Free fatty acid receptor 1 (GPR40) |
|