TARGETID

T13629

UNIPROID

PDCD1_HUMAN-PD1L1_HUMAN

TARGNAME

PD-1-PD-L1 interaction (PD-1/PD-L1 PPI)

GENENAME

PDCD1-CD274

TARGTYPE

Patented-recorded target

SYNONYMS

Programmed cell death 1/Programmed cell death 1 ligand 1 PPI

FUNCTION

The PD-1/PD-L1 axis is probably also important for immune evasion of B-cell lymphomas with a viral aetiology, including those associated with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV).

SEQUENCE

MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEETMQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL

DRUGINFO

1,2,4-oxadiazole derivative 4

DRUGINFO

1,2,4-oxadiazole derivative 5

DRUGINFO

1,2,4-oxadiazole derivative 6

DRUGINFO

1,2,4-oxadiazole derivative 7

DRUGINFO

1,3,4-oxadiazole derivative 3

DRUGINFO

1,3,4-oxadiazole derivative 4

DRUGINFO

1,3,4-oxadiazole derivative 5

DRUGINFO

1,3,4-oxadiazole derivative 6

DRUGINFO

1,3,4-thiadiazole derivative 1

DRUGINFO

1,3,4-thiadiazole derivative 2

DRUGINFO

1,3-dihydroxy phenyl derivative 1

DRUGINFO

1,3-dihydroxy phenyl derivative 2