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靶点信息25(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Succinate-semialdehyde dehydrogenase (ALDH5A1)
TARGTYPE
Successful target
SYNONYMS
Succinic dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1
FUNCTION
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
PDBSTRUC
2W8R; 2W8Q; 2W8P; 2W8O; 2W8N
BIOCLASS
Aldehyde/oxo donor oxidoreductase
SEQUENCE
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
DRUGINFO
1-(4-hydroxyphenyl)prop-2-en-1-one
KEGGPATH
hsa00250:Alanine, aspartate and glutamate metabolism
KEGGPATH
hsa00650:Butanoate metabolism
KEGGPATH
hsa01100:Metabolic pathways
WIKIPATH
WP2685:GABA synthesis, release, reuptake and degradation
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00250 |
|
| hsa00650 |
|
| hsa01100 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Succinate-semialdehyde dehydrogenase (ALDH5A1) |
|