TARGETID

T13127

UNIPROID

FNTA_HUMAN; FNTB_HUMAN

TARGNAME

Farnesyl protein transferase (Ftase)

GENENAME

FNTB; FNTA

SYNONYMS

Ras proteins prenyltransferase; Protein farnesyltransferase; Ftase; CAAX farnesyltransferase

FUNCTION

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1prenylation and activation.

BIOCLASS

Alkyl aryl transferase

SEQUENCE

MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ

DRUGINFO

Lonafarnib

DRUGINFO

Zarnestra

DRUGINFO

BMS214662

DRUGINFO

GGTI-2418

DRUGINFO

L-778123

DRUGINFO

ABT-839

DRUGINFO

AZD3409

DRUGINFO

L-731735

DRUGINFO

L-745631

DRUGINFO

MANUMYCIN A

DRUGINFO

RPR-113829

DRUGINFO

RPR-114334