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靶点信息21(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Troponin C (TN-C)
TARGTYPE
Successful target
SYNONYMS
Troponin C, slow skeletal and cardiac muscles; TNNC
FUNCTION
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
PDBSTRUC
6MV3; 5WCL; 5W88; 5VLN; 4Y99
SEQUENCE
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
DRUGINFO
Dihydroxyaluminium
KEGGPATH
hsa04020:Calcium signaling pathway
KEGGPATH
hsa04260:Cardiac muscle contraction
KEGGPATH
hsa04261:Adrenergic signaling in cardiomyocytes
KEGGPATH
hsa05410:Hypertrophic cardiomyopathy (HCM)
KEGGPATH
hsa05414:Dilated cardiomyopathy
WIKIPATH
WP1864:Muscle contraction
WIKIPATH
WP383:Striated Muscle Contraction
WHIZPATH
PW000564:Muscle/Heart Contraction
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04020 |
|
| hsa04260 |
|
| hsa04261 |
|
| hsa05410 |
|
| hsa05414 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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