TARGETID

T12091

FORMERID

TTDI03010

UNIPROID

ACVR1_HUMAN

TARGNAME

Activin receptor-like kinase 2 (ALK-2)

GENENAME

ACVR1

TARGTYPE

Clinical trial target

SYNONYMS

TSR-I; TGF-B superfamily receptor type I; Serine/threonine-protein kinase receptor R1; SKR1; Activin receptor type-1; Activin receptor type I; ACVRLK2; ACTR-I

FUNCTION

Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

PDBSTRUC

6GIP; 6GIN; 6GI6; 6EIX; 6ACR

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.30

SEQUENCE

MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

DRUGINFO

INCB00928

DRUGINFO

TP-0184

DRUGINFO

PMID27774822-Compound-Figure10Compound12

DRUGINFO

PMID27774822-Compound-Figure10Compound4

DRUGINFO

LDN-214117

DRUGINFO

ML347

DRUGINFO

PMID23639540C13a

DRUGINFO

PMID23639540C13d