靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T10052

FORMERID

TTDR00786

UNIPROID

CCNE1_HUMAN

TARGNAME

G1/S-specific cyclin-E1 (CCNE1)

GENENAME

CCNE1

TARGTYPE

Literature-reported target

SYNONYMS

G1/S-specific cyclin E; Cyclin E; CCNE

FUNCTION

Essential for the control of the cell cycle at the G1/S (start) transition.

PDBSTRUC

5L2W; 1W98

SEQUENCE

MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

DRUGINFO

D0Z0KD

PD-0183812

Terminated

DRUGINFO

D01PSU

(2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime

Investigative

DRUGINFO

D0B1LM

(2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime

Investigative

DRUGINFO

D0JR0G

(2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime

Investigative

DRUGINFO

D03KLM

(2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime

Investigative

DRUGINFO

D06XIW

(2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime

Investigative

DRUGINFO

D06GLV

(2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime

Investigative

DRUGINFO

D0J3RS

(2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime

Investigative

DRUGINFO

D04AGE

(2'Z,3'E)-5-Fluoro-5'-methoxy-indirubin-3'-oxime

Investigative

DRUGINFO

D0W2FM

(2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04115	p53 signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa05161	Hepatitis B
hsa05162	Measles
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05206	MicroRNAs in cancer
hsa05215	Prostate cancer
hsa05222	Small cell lung cancer

目标的 Wiki 路径数据

标题	内容
WP707	DNA Damage Response
WP53	ID signaling pathway
WP45	G1 to S cell cycle control
WP2446	Retinoblastoma (RB) in Cancer
WP2377	Integrated Pancreatic Cancer Pathway
WP2371	Parkinsons Disease Pathway
WP2359	Parkin-Ubiquitin Proteasomal System pathway
WP2261	Signaling Pathways in Glioblastoma
WP2032	TSH signaling pathway
WP1858	Mitotic G1-G1/S phases
WP179	Cell Cycle
WP1545	miRNAs involved in DNA damage response
WP1530	miRNA Regulation of DNA Damage Response
WP138	Androgen receptor signaling pathway

目标的蛋白质ID

标题	内容
TARGETID	T10052
UNIPROID	CCNE1_HUMAN
TARGNAME	G1/S-specific cyclin-E1 (CCNE1)
TARGTYPE	Research target

目标的序列数据

标题	内容
G1/S-specific cyclin-E1 (CCNE1)	MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

标题

内容

G1/S-specific cyclin-E1 (CCNE1)

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