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靶点信息

标题

内容

相关药物

状态

TARGETID

T09058

FORMERID

TTDR00714

UNIPROID

TPBG_HUMAN

TARGNAME

Oncotrophoblast glycoprotein 5T4 (TPBG)

GENENAME

TPBG

TARGTYPE

Clinical trial target

SYNONYMS

Trophoblast glycoprotein; TPBG

FUNCTION

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization.

PDBSTRUC

4CNM; 4CNC

SEQUENCE

MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

DRUGINFO

D0L1OT

TroVax

Phase 3

DRUGINFO

D0T8HR

Naptumomab estafenatox

DRUGINFO

CV-9201

DRUGINFO

GEN1044

DRUGINFO

PF-06263507

DRUGINFO

Anatumomab mafenatox

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T09058
UNIPROID	TPBG_HUMAN
TARGNAME	Oncotrophoblast glycoprotein 5T4 (TPBG)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Oncotrophoblast glycoprotein 5T4 (TPBG)	MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

标题

内容

Oncotrophoblast glycoprotein 5T4 (TPBG)

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