TARGETID

T08583

FORMERID

TTDR00395

UNIPROID

TRBM_HUMAN

TARGNAME

Thrombomodulin (THBD)

GENENAME

THBD

TARGTYPE

Discontinued target

SYNONYMS

TM; THRM; Fetomodulin; CD141 antigen; CD141

FUNCTION

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

PDBSTRUC

5TO3; 3GIS; 2ADX; 1ZAQ; 1TMR

BIOCLASS

Growth factor

SEQUENCE

MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL

DRUGINFO

Thrombomodulin

KEGGPATH

hsa04610:Complement and coagulation cascades

WIKIPATH

WP1794:Cell surface interactions at the vascular wall

WIKIPATH

WP1818:Formation of Fibrin Clot (Clotting Cascade)

WIKIPATH

WP2877:Vitamin D Receptor Pathway

WIKIPATH

WP2882:Nuclear Receptors Meta-Pathway

WIKIPATH

WP558:Complement and Coagulation Cascades

REACPATH

R-HSA-140875:Common Pathway of Fibrin Clot Formation

REACPATH

R-HSA-202733:Cell surface interactions at the vascular wall