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靶点信息24(本栏目收费,不能显示细节,电话15274084725)
靶点信息
TARGNAME
B-cell-specific glycoprotein B29 (CD79B)
SYNONYMS
Immunoglobulinassociated B29 protein; Immunoglobulin-associated B29 protein; Igbeta; Ig-beta; IGB; CD79b; Bcellspecific glycoprotein B29; Bcell antigen receptor complexassociated protein beta chain; B29; B-cell antigen receptor complex-associated protein beta chain
FUNCTION
Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.
SEQUENCE
MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE
DRUGINFO
Polatuzumab vedotin
DRUGINFO
CD79-targeted immunotoxins
KEGGPATH
hsa04662:B cell receptor signaling pathway
WIKIPATH
WP23:B Cell Receptor Signaling Pathway
WIKIPATH
WP2746:Signaling by the B Cell Receptor (BCR)
REACPATH
R-HSA-983695:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
目标的蛋白质ID
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目标的序列数据
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| B-cell-specific glycoprotein B29 (CD79B) |
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