当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话15274084725)
靶点信息34(本栏目收费,不能显示细节,电话15274084725)
靶点信息
TARGNAME
Granzyme B (GZMB)
TARGTYPE
Literature-reported target
SYNONYMS
Tcell serine protease 13E; SECT; Lymphocyte protease; Human lymphocyte protein; Granzyme2; GZMB; Fragmentin2; Cytotoxic Tlymphocyte proteinase 2; Cathepsin Glike 1; CTSGL1; CTLA1; C11
FUNCTION
This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9and 10 to give rise to active enzymes mediating apoptosis.
SEQUENCE
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
KEGGPATH
hsa04650:Natural killer cell mediated cytotoxicity
KEGGPATH
hsa04940:Type I diabetes mellitus
KEGGPATH
hsa05202:Transcriptional misregulation in cancer
KEGGPATH
hsa05320:Autoimmune thyroid disease
KEGGPATH
hsa05330:Allograft rejection
KEGGPATH
hsa05332:Graft-versus-host disease
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04650 |
|
| hsa04940 |
|
| hsa05202 |
|
| hsa05320 |
|
| hsa05330 |
|
| hsa05332 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP623 |
|
| WP2718 |
|
| WP254 |
|
| WP2328 |
|
| WP1841 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|