TARGETID

T08231

FORMERID

TTDI02091

UNIPROID

HG2A_HUMAN

TARGNAME

HLA-DR antigens-associated invariant (CD74)

GENENAME

CD74

TARGTYPE

Clinical trial target

SYNONYMS

Ii; Ia antigenassociated invariant chain; Ia antigen-associated invariant chain; HLADR antigensassociated invariant chain; HLA-DR antigens-associated invariant chain; HLA class II histocompatibility antigen gamma chain; DHLAG

FUNCTION

Serves as cell surface receptor for the cytokine MIF. Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place.

PDBSTRUC

5KSV; 5KSU; 4X5W; 4AH2; 4AEN

SEQUENCE

MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

DRUGINFO

Milatuzumab

KEGGPATH

hsa04612:Antigen processing and presentation

KEGGPATH

hsa05152:Tuberculosis

KEGGPATH

hsa05168:Herpes simplex infection

WIKIPATH

WP2679:MHC class II antigen presentation

REACPATH

R-HSA-2132295:MHC class II antigen presentation

NET_PATH

NetPath_23:TSH Signaling Pathway

PANTPATH

P00053:T cell activation