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靶点信息31(本栏目收费,不能显示细节,电话15274084725)
靶点信息
TARGNAME
Erythropoietin (EPO)
TARGTYPE
Clinical trial target
FUNCTION
Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
PDBSTRUC
1EER; 1CN4; 1BUY
SEQUENCE
MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
DRUGINFO
Erythropoietin-transfected autologous cell therapy
DRUGINFO
Long-acting erythropoietin conjugate
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04066:HIF-1 signaling pathway
KEGGPATH
hsa04151:PI3K-Akt signaling pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04066 |
|
| hsa04151 |
|
| hsa04630 |
|
| hsa04640 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP581 |
|
| WP2849 |
|
| WP2848 |
|
| WP2727 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Erythropoietin (EPO) |
|